Frontiers in bioengineering and biotechnology · 2025
High-frame-rate ultrasound analysis of gastric peristalsis using the peristaltic analyzer: a pilot feasibility study.
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Han Li, Li Tingting, Zhuang Min, Li Yuan, He Chuanshi, Zhang Zijian, Lu Man
Аннотация
BACKGROUND: Gastric peristalsis plays a pivotal role in regulating gastric emptying and digestive function. However, current clinical assessments of gastric motility primarily rely on invasive or low-temporal-resolution techniques, which fail to support dynamic, real-time evaluations.
METHODS: We innovatively extended the Peristaltic Analyzer (PA)-a high-frame-rate ultrasound technology originally designed for endometrial wave analysis to the assessment of gastric peristalsis. Utilizing submicron displacement tracking and spatiotemporal vector analysis, we conducted real-time visualization and quantitative evaluation of gastric motility in 9 healthy volunteers.
RESULTS: All participants completed image acquisition and peristaltic tracking. The detected peristaltic waves consistently propagated from the proximal to the distal stomach, with an average propagation speed of 1.99 ± 0.18 mm/s, propagation distance of 3.23 ± 0.33 cm, peristaltic intensity of 4.76 ± 1.52 (relative units), interval of 17.31 ± 0.86 s, and frequency of 3.53 ± 0.19 bpm. Waveforms appeared continuous and rhythmic, with uniform propagation direction and clear spatiotemporal profiles.
CONCLUSION: As the first application of the PA high-frame-rate peristaltic analysis technology to gastric motility assessment, this study demonstrates its strong potential as a non-invasive and real-time tool for early detection, quantitative monitoring, and clinical evaluation of functional gastrointestinal disorders. PA exhibited superior performance in motion detection, directional analysis, and fine-scale displacement measurement. These capabilities highlight its potential as a novel tool for early identification and longitudinal monitoring of functional gastrointestinal disorders, postoperative gastric dysmotility, and diabetic gastroparesis, offering substantial clinical translational value and applicability.
METHODS: We innovatively extended the Peristaltic Analyzer (PA)-a high-frame-rate ultrasound technology originally designed for endometrial wave analysis to the assessment of gastric peristalsis. Utilizing submicron displacement tracking and spatiotemporal vector analysis, we conducted real-time visualization and quantitative evaluation of gastric motility in 9 healthy volunteers.
RESULTS: All participants completed image acquisition and peristaltic tracking. The detected peristaltic waves consistently propagated from the proximal to the distal stomach, with an average propagation speed of 1.99 ± 0.18 mm/s, propagation distance of 3.23 ± 0.33 cm, peristaltic intensity of 4.76 ± 1.52 (relative units), interval of 17.31 ± 0.86 s, and frequency of 3.53 ± 0.19 bpm. Waveforms appeared continuous and rhythmic, with uniform propagation direction and clear spatiotemporal profiles.
CONCLUSION: As the first application of the PA high-frame-rate peristaltic analysis technology to gastric motility assessment, this study demonstrates its strong potential as a non-invasive and real-time tool for early detection, quantitative monitoring, and clinical evaluation of functional gastrointestinal disorders. PA exhibited superior performance in motion detection, directional analysis, and fine-scale displacement measurement. These capabilities highlight its potential as a novel tool for early identification and longitudinal monitoring of functional gastrointestinal disorders, postoperative gastric dysmotility, and diabetic gastroparesis, offering substantial clinical translational value and applicability.