In vivo (Athens, Greece) · 2026
Clinical Features, Prognosis, and Prognostic Factors of Remnant Gastric Cancer Patients Who Received Potentially Curative Gastrectomy.
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Aoyama Toru, Cho Haruhiko, Suematsu Hideaki, Hara Kentaro
Аннотация
BACKGROUND/AIM: Remnant gastric cancer (RGC) is technically difficult for surgery due to adhesion of remnant stomach to surrounding organs. To optimize RGC treatment, it is necessary to clarify the clinical features and prognostic factors of RGC. Therefore, we aimed to clarify the clinical features and prognostic factors of RGC.
PATIENTS AND METHODS: The patients were selected from the consecutive database of the Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Department of Gastric Surgery, according to the following criteria: (i) histologically-proven gastric adenocarcinoma, (ii) patients who underwent curative gastrectomy for gastric cancer as a primary treatment and archived R0 resection between 2005 and 2025. RGC is defined as GC develops at the remnant stomach after gastrectomy for benign or malignant disease.
RESULTS: A total of 2,013 patients were eligible for the present study. In the present study, 45 patients were categorized as the RGC group, and 1,968 patients were in the non-RGC group. When comparing the patient background between RGC group and non-RGC group, significant differences were observed in median age (72 years vs. 69 years, p=0.042), preoperative body mass index (BMI) (21.3 vs. 22.5, p=0.004), and clinical lymph node metastasis (11.1% vs. 29.4%, p=0.007). Three- and five-year OS were 83.4% and 78.5% in RGC group, 85.3% and 81.0% in non-RGC group, respectively. No significant differences were found (p=0.529). In the prognostic analysis of RGC, lymphatic invasion was an independent prognostic factors for OS [hazard ratio (HR)=10.245, 95% confidence interval (CI)=1.150-91.281, p=0.037].
CONCLUSION: Although there are surgical, perioperative diagnosis, and tumor evaluation difficulties in RGC treatment, the survival of RGC patients was almost similar to non-RGC patients. RGC patients with lymphatic invasion were poorer than those without lymphatic invasion.
PATIENTS AND METHODS: The patients were selected from the consecutive database of the Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Department of Gastric Surgery, according to the following criteria: (i) histologically-proven gastric adenocarcinoma, (ii) patients who underwent curative gastrectomy for gastric cancer as a primary treatment and archived R0 resection between 2005 and 2025. RGC is defined as GC develops at the remnant stomach after gastrectomy for benign or malignant disease.
RESULTS: A total of 2,013 patients were eligible for the present study. In the present study, 45 patients were categorized as the RGC group, and 1,968 patients were in the non-RGC group. When comparing the patient background between RGC group and non-RGC group, significant differences were observed in median age (72 years vs. 69 years, p=0.042), preoperative body mass index (BMI) (21.3 vs. 22.5, p=0.004), and clinical lymph node metastasis (11.1% vs. 29.4%, p=0.007). Three- and five-year OS were 83.4% and 78.5% in RGC group, 85.3% and 81.0% in non-RGC group, respectively. No significant differences were found (p=0.529). In the prognostic analysis of RGC, lymphatic invasion was an independent prognostic factors for OS [hazard ratio (HR)=10.245, 95% confidence interval (CI)=1.150-91.281, p=0.037].
CONCLUSION: Although there are surgical, perioperative diagnosis, and tumor evaluation difficulties in RGC treatment, the survival of RGC patients was almost similar to non-RGC patients. RGC patients with lymphatic invasion were poorer than those without lymphatic invasion.