British dental journal · 1998
Is there a link between periodontal disease and coronary heart disease?
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Seymour R A, Steele J G
Аннотация
OBJECTIVE: To provide a critical review of the studies completed to date that have investigated a link between coronary heart disease and dental health.
DESIGN: Retrospective analysis.
SETTING: Mainly hospital-based patients or subjects involved in longitudinal health care studies.
MAIN OUTCOME MEASURES: The incidence of coronary heart disease and its relationship to dental health and other recognised risk factors.
RESULTS: Evidence suggests that dental health, in particular periodontal disease, may be a significant risk factor for coronary heart disease and further coronary events. Possible biological mechanisms that link the two diseases are appraised.
CONCLUSIONS: There does appear to be increasing evidence that a relationship exists between dental health and coronary heart disease, especially in males aged 40-50 years. The presence of a hyperinflammatory monocyte phenotype may provide a common biological mechanism that links the two diseases.
DESIGN: Retrospective analysis.
SETTING: Mainly hospital-based patients or subjects involved in longitudinal health care studies.
MAIN OUTCOME MEASURES: The incidence of coronary heart disease and its relationship to dental health and other recognised risk factors.
RESULTS: Evidence suggests that dental health, in particular periodontal disease, may be a significant risk factor for coronary heart disease and further coronary events. Possible biological mechanisms that link the two diseases are appraised.
CONCLUSIONS: There does appear to be increasing evidence that a relationship exists between dental health and coronary heart disease, especially in males aged 40-50 years. The presence of a hyperinflammatory monocyte phenotype may provide a common biological mechanism that links the two diseases.
Предметные рубрики MeSH
AdultAge FactorsAgedBiologyCausalityCerebrovascular DisordersCoronary DiseaseDentist-Patient RelationsFemaleFocal Infection, DentalGram-Negative BacteriaHemostasisHumansIncidenceInflammation MediatorsLiability, LegalLongitudinal StudiesMaleMiddle AgedMonocytesMotivationPeriodontal DiseasesPhenotypeRetrospective StudiesRisk FactorsSex FactorsThromboembolismTooth Extraction