Local and systemic therapeutics for the control of endodontic pain.

Endodontic pain is best managed by eliminating the source as completely as possible. When it is determined that drugs are required, judicious use of local anesthetics and nonopioid analgesics can be beneficial and provide the first course of action. When it is determined that the pain will not be managed by these measures alone, the addition of an opioid analgesic may be considered with the understanding that more adverse side effects attend their use.