[The local activation of leukocytes and thrombocytes in periodontal diseases: the role of thrombocyte-activating factor].

Concentration of markers for platelet and leukocyte local activation including platelets factor four, beta-thromboglobulin, granulyte elastate and beta-glucunidase was measured in gingival fluid from patients with gingivitis and periodontitis. It has been shown that there is a statistically significant increase in level of markers in these patients. The increase correlated with degree of periodontal injury. Radioimmune assay of concentrations of platelet-activating factor (PAF) in gingival fluid and gingival tissue was performed. Its concentration also increased in gingivitis and periodontitis depending on intensity of the tissue injury. A close correlation between the PAF concentration has been revealed. It is likely that hypergeneration of PAF in the endothelium is a mechanism for the blood cell activation and accumulation in gingival tissue resulting in its failure due to secretion of different deleterious agents from the activated cells.