Effectiveness of Nurse-Coordinated, Digital-Supported Collaborative Care Model in Reducing Hospital Stay and Mortality Among Patients With Heart Failure: TIME-HF Cluster RCT India.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Jeemon Panniyammakal, Ganapathi Sanjay, Anikkady Navya, Ismail Sunaib, Unni Govindan, Bahuleyan Charantharayil Gopalan, Meera Renukadevi, Daniel Rachel, Joseph Stigi, Gnanaraj Justin Paul, Pisharody Sunil, Edakutty Rajeev, Joseph Johny, Abdullakutty Jabir, Nair Tiny, Athira Thottathan, Alex Mariyam, Jojo Alan, Rajendiran Gopalan, Balakrishnan Jayakumar, Kandathil Joyal J, Sreedharan Madhu, Mahesh Nalin Kumar, Thomas Paul, Ganesan Vijayan, Sebastian Placid, Ahmad Sajan, Salahuddin Salman, Mattummal Shafeeq, Nanjappa Veena, George Vijo, Punnoose Eapen, Syam N, Harikrishnan Sivadasanpillai, TIME-HF Collaborators
Аннотация
METHODS: We conducted a parallel-group, cluster-randomized controlled trial involving 1507 adults with heart failure with reduced ejection fraction across 22 centers in India (CTRI/2021/11/037797). Centers were randomized 1:1 to the intervention or usual care. Participants were followed up for 2 years. The intervention included risk stratification, lifestyle and pharmacological optimization, and a nurse-coordinated, mobile health-supported disease management program with self-care education, active follow-up, and continuous outpatient monitoring throughout the study period. The primary outcome was days alive and out of the hospital, and all-cause mortality was assessed as a secondary outcome. Days alive and out of the hospital was analyzed with a one-inflated β model. All-cause mortality was analyzed with Cox proportional hazards models adjusted for the clustered study design.
RESULTS: Among 1507 participants (752 usual care; 755 intervention), the mean age was 61.9 years, and 77.6% were men. All participants except one completed 24 months of follow-up. Most participants (70%) had low educational attainment; 57.3% lived in rural areas; and ischemic heart disease was the predominant cause (77.4%). Baseline characteristics were comparable between the intervention and usual care groups. In the one-inflated β model, the probability of surviving up to 730 days without hospitalization was 34.7% (95% CI, 31.2%-38.1%) in the usual care group and 46.5% (95% CI, 42.6%-49.9%) in the intervention group. Participants in the intervention group had 78% higher odds of achieving a percent days alive and out of the hospital of exactly 1 (730/730 days) compared with those in the usual care group (odds ratio, 1.78 [95% CI, 1.42-2.23]). There were 201 deaths (26.73%) in the usual care group compared with 163 deaths (21.59%) in the intervention group (risk ratio, 0.80 [95% CI, 0.67-0.97]). In the multivariable Cox proportional hazards model, the intervention group had a 22% lower mortality risk than the usual care group (hazard ratio, 0.78 [95% CI, 0.63-0.95]; P=0.028).
CONCLUSIONS: A nurse-coordinated, mobile health-supported collaborative care model for heart failure with reduced ejection fraction in India increased the number of days alive and out of hospital, raised the absolute probability of remaining out of hospital by 11.8 percentage points, and reduced all-cause mortality by 22%.
REGISTRATION: URL: www.ctri.nic.in; Unique identifier: CTRI/2021/11/037797.