Translational cancer research · 2020
Incidence, treatment, and survival analysis in mediastinal malignant teratoma population.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Rujuan, Li Hao, Jiang Jie, Xu Guoxing
Аннотация
BACKGROUND: Mediastinal malignant teratoma, as a germ cell tumor, is rare and lacking of population-based study. This study aims to illustrate the incidence, treatment and prognosis of mediastinal malignant teratoma by using a population-based database.
METHODS: We gathered clinicopathological data (1975-2016) of malignant teratoma from the Surveillance, Epidemiology and End Results (SEER) database. Then we conducted analysis on the incidence, treatment and prognosis of mediastinal malignant teratoma and other malignant teratomas.
RESULTS: A total of 5,550 cases were in our study cohort, including mediastinal malignant teratoma (n=133) and other malignant teratomas (n=5,417). The incidence of mediastinal malignant teratoma in 2016 was 0.004 per 100,000 persons. Both overall survival (OS) and cancer-specific survival (CSS) of mediastinal malignant teratoma were significantly worse than those of other malignant teratomas (both P<0.001). Surgery significantly improved OS and CSS of either early-staged or all-staged patients with mediastinal malignant teratoma (all P<0.001). However, both chemotherapy and radiotherapy negatively influenced both OS and CSS of patients with mediastinal malignant teratomas (all P<0.001). Besides, compared with surgery alone, combinational therapies like surgery + chemotherapy or surgery + radiotherapy were more harmful to OS and CSS (all P<0.001) of patients with mediastinal malignant teratoma.
CONCLUSIONS: Our population-based evidence showed that mediastinal malignant teratoma, a rare cancer, had worse prognosis compared with other malignant teratomas. Compared with chemotherapy and radiotherapy, surgery could yield more survival benefits for either early-staged or all-staged patients with mediastinal malignant teratoma. Adjuvant use of chemotherapy/radiotherapy to surgery cannot improve but potentially harm patient prognosis.
METHODS: We gathered clinicopathological data (1975-2016) of malignant teratoma from the Surveillance, Epidemiology and End Results (SEER) database. Then we conducted analysis on the incidence, treatment and prognosis of mediastinal malignant teratoma and other malignant teratomas.
RESULTS: A total of 5,550 cases were in our study cohort, including mediastinal malignant teratoma (n=133) and other malignant teratomas (n=5,417). The incidence of mediastinal malignant teratoma in 2016 was 0.004 per 100,000 persons. Both overall survival (OS) and cancer-specific survival (CSS) of mediastinal malignant teratoma were significantly worse than those of other malignant teratomas (both P<0.001). Surgery significantly improved OS and CSS of either early-staged or all-staged patients with mediastinal malignant teratoma (all P<0.001). However, both chemotherapy and radiotherapy negatively influenced both OS and CSS of patients with mediastinal malignant teratomas (all P<0.001). Besides, compared with surgery alone, combinational therapies like surgery + chemotherapy or surgery + radiotherapy were more harmful to OS and CSS (all P<0.001) of patients with mediastinal malignant teratoma.
CONCLUSIONS: Our population-based evidence showed that mediastinal malignant teratoma, a rare cancer, had worse prognosis compared with other malignant teratomas. Compared with chemotherapy and radiotherapy, surgery could yield more survival benefits for either early-staged or all-staged patients with mediastinal malignant teratoma. Adjuvant use of chemotherapy/radiotherapy to surgery cannot improve but potentially harm patient prognosis.