Orthodontics & craniofacial research · 2025
miRNA-337-3p and Matrix Metalloproteinase-9: Expression Patterns in Oral Squamous Cell Carcinoma and Prognostic Value for Cervical Lymph Node Metastasis.
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Xu Hongyan, Zhang Peng, Yang Ying, Li Jianhu, Xu Jiaqiang, Wang Tao
Аннотация
OBJECTIVE: To explore the expression of matrix metalloproteinase 9 and miRNA-337-3p in oral squamous cell carcinoma tissues and analyse their clinical significance.
MATERIALS AND METHODS: Postoperative specimens from 30 oral squamous cell carcinoma (OSCC) patients were collected from June 2022 to January 2023, and real-time fluorescence quantitative reverse transcription PCR was used to detect the expression levels of miR-337-3p in cancer tissues and adjacent normal tissues. The correlation between the expression levels of the two and the clinicopathological parameters of patients was analysed.
RESULTS: Compared with adjacent normal tissues, the expression of miRNA-337-3p in OSCC tissues was significantly lower (p < 0.05), and its expression level was clearly related to the lymph node metastasis status of OSCC patients (p < 0.05). The positive rates of MMP-9 in OSCC tissue and adjacent normal tissue were 83.33% and 36.67% respectively. Compared with patients in the N0 stage, the expression level of miRNA-337-3p in OSCC tissues of patients in the N1 + N2 stage was significantly reduced (p < 0.05).
CONCLUSION: The expression of MMP-9 and miRNA-337-3p in OSCC tissues is related to cervical lymph node metastasis. miRNA-337-3p plays a tumour suppressor role in OSCC and may inhibit OSCC cell invasion and metastasis.
MATERIALS AND METHODS: Postoperative specimens from 30 oral squamous cell carcinoma (OSCC) patients were collected from June 2022 to January 2023, and real-time fluorescence quantitative reverse transcription PCR was used to detect the expression levels of miR-337-3p in cancer tissues and adjacent normal tissues. The correlation between the expression levels of the two and the clinicopathological parameters of patients was analysed.
RESULTS: Compared with adjacent normal tissues, the expression of miRNA-337-3p in OSCC tissues was significantly lower (p < 0.05), and its expression level was clearly related to the lymph node metastasis status of OSCC patients (p < 0.05). The positive rates of MMP-9 in OSCC tissue and adjacent normal tissue were 83.33% and 36.67% respectively. Compared with patients in the N0 stage, the expression level of miRNA-337-3p in OSCC tissues of patients in the N1 + N2 stage was significantly reduced (p < 0.05).
CONCLUSION: The expression of MMP-9 and miRNA-337-3p in OSCC tissues is related to cervical lymph node metastasis. miRNA-337-3p plays a tumour suppressor role in OSCC and may inhibit OSCC cell invasion and metastasis.