[The pharmacodynamic and ulcer-healing action of modern anti-ulcer agents].

In a study of 159 duodenal ulcer patients the authors studied the effect of H2-blockers, antibacterial and sucralfate monotherapy on the frequency of the ulcer healing, Helicobacter pylori (HP) infection and acid-proteolytic aggression in the body and antropyloric portion of the stomach. All the drugs were found to exhibit similar antiulcer activity. Inhibition of the acid-proteolytic aggression in the gastric body was registered only under the action of H2-blockers. Antibacterial preparations inhibited the growth of HP, but did not affect the acidity and proteolysis in the gastric body. Neither did sucralfate which also had no effect on microorganisms. All the test drugs were able to reduce antropyloric acidity, thus promoting healing of the ulcer.