[Duodenogastric reflux and Helicobacter pylori infection in chronic gastritis--evaluation of risk factor significance and risk factor interactions].

Among 184 sick persons with chronic gastritis proved histologicaly, frequency of appearance of duodenal gastric reflux was estimated scintigraphically, and frequency of appearance of IgG against Helicobacter pylori by serologic test (ELISA and IFP). Reflux was proved in 70 (38%) cases, whereas in 152 (82.6%) specific IgG was found. Using GLM program in the statistic analysis it was found that impact of each of these factors on inflammatory changed gastric mucous membrane is different. The weakest impact of reflex was on appearance of GChA in stomach, impact was 1.9 times higher on appearance of GChpA, GChSimp.--6.4 times higher and of GChSup. as high as 23.9 times. Whereas the weakest impact of Helicobacter pylori was on appearance of GChSimp. in stomach, in appearance of GChSup. the impact was 1.4 times higher, GChpA--1.9 times higher, while GChA 2.1 times higher. Taking into consideration interaction between reflux and infection it was proved that bacterial factor (Helicobacter pylori) acts on gastric mucous membrane (except chronic superficial inflammation) from 2.3 to 30.1(!) times higher (depending on form of chronic inflammation) than duodenal-gastric reflux.