Eye (London, England) · 2025
Quantitative assessment of hyperreflective dots in the outer nuclear layer over neovascular lesion components.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Keshet Yariv, Ngo Wei Kiong, Salcedo-Ledesma Alfredo, Walia Jasjit Jay, Spaide Richard F
Аннотация
OBJECTIVES: To evaluate the outer nuclear layer for hyperreflective dots (HRD), a proposed imaging correlate of retinal microglia, in eyes with neovascular age-related macular degeneration (nAMD).
METHODS: High-resolution optical coherence tomography (OCT) of eyes with nAMD was evaluated with the aid of a custom ImageJ plugin that automatically identified HRD and plotted them on the corresponding near infrared (IR) fundus image. Areas of subretinal fluid (SRF), double layer sign (DLS), and the area of neovascularisation as imaged by OCT angiography (A) were mapped to the near-IR image. The number of HRD overlying these regions was tabulated.
RESULTS: There were 38 eyes of 38 patients. SRF was present in 23 eyes, there was a median 8.5 HRD /mm2 over this area. DLS was present in all eyes and with a median of 6.5 HRD/mm2 over this area. Neovascularisation was detectable using OCTA with a median of 6.8 HRD/mm2. The density of HRD/mm2 was not significantly different over areas of DLS with fluid compared to areas of DLS without SRF (P = 0.22). The median HRD/mm2 for uninvolved areas of the retina was 0.7, a difference that was significantly less than over areas of SRF, DLS, and OCTA detected neovascularisation (P < 0.001 for all comparisons).
CONCLUSIONS: There is an aggregation of HRD in the outer retina over lesion components of nAMD. These HRD may be present in response to SRF, but their existence over regions of the neovascular lesion without SRF suggests that additional factors are involved in their recruitment.
METHODS: High-resolution optical coherence tomography (OCT) of eyes with nAMD was evaluated with the aid of a custom ImageJ plugin that automatically identified HRD and plotted them on the corresponding near infrared (IR) fundus image. Areas of subretinal fluid (SRF), double layer sign (DLS), and the area of neovascularisation as imaged by OCT angiography (A) were mapped to the near-IR image. The number of HRD overlying these regions was tabulated.
RESULTS: There were 38 eyes of 38 patients. SRF was present in 23 eyes, there was a median 8.5 HRD /mm2 over this area. DLS was present in all eyes and with a median of 6.5 HRD/mm2 over this area. Neovascularisation was detectable using OCTA with a median of 6.8 HRD/mm2. The density of HRD/mm2 was not significantly different over areas of DLS with fluid compared to areas of DLS without SRF (P = 0.22). The median HRD/mm2 for uninvolved areas of the retina was 0.7, a difference that was significantly less than over areas of SRF, DLS, and OCTA detected neovascularisation (P < 0.001 for all comparisons).
CONCLUSIONS: There is an aggregation of HRD in the outer retina over lesion components of nAMD. These HRD may be present in response to SRF, but their existence over regions of the neovascular lesion without SRF suggests that additional factors are involved in their recruitment.