A Multi-Degradation Fundus Image Restoration Network Guided by Frequency Prompt.

High-quality fundus images are critical for clinical diagnosis, yet real-world acquisition challenges often introduce multi-component degradations. Current deep learning methods typically address single degradations, lacking a unified handling of complex scenarios. In this paper, we propose the Multi-degradation Fundus Image Restoration Network (MFR-Net), an all-in-one restoration framework integrating frequency-aware prompt learning. MFR-Net comprehensively extracts the frequency domain features of different degradation components, and injects them into the backbone network through designed prompt generation and interaction modules. Furthermore, to enhance the model's domain generalization capability, the unsupervised domain adaptation is incorporated into a more reliable perceptual and image quality-oriented space for domain alignment. Extensive experimental results demonstrate that the proposed method outperforms several state-of-the-art models in the restoration of degraded retinal images, especially in the restoration of complex degradations in real images, where the quantitative indicators have been improved by up to 5.42% compared with SOTA algorithms.