Japanese journal of radiology · 2012
A quantitative index measured on ⁹⁹mTc GSA SPECT/CT 3D fused images to evaluate severe fibrosis in patients with chronic liver disease.
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Yoshida Morikatsu, Shiraishi Shinya, Sakaguchi Fumi, Utsunomiya Daisuke, Tashiro Kuniyuki, Tomiguchi Seiji, Okabe Hirohisa, Beppu Toru, Baba Hideo, Yamashita Yasuyuki
Аннотация
PURPOSE: We compared quantitative indices estimated by use of technetium-(99m) galactosyl human serum albumin ((99m)Tc-GSA) single-photon emission computed tomography (SPECT)/computed tomography (CT) fused imaging and hepatic fibrosis in patients with chronic liver disease.
MATERIALS AND METHODS: On the basis of pathological findings we divided 161 patients into non-severe and severe fibrosis groups (n = 81 and n = 80, respectively). We measured 2 indices by (99m)Tc-GSA SPECT/CT fused imaging: liver uptake value (LUV) = [radioactivity (whole liver)/radioactivity (injected)] × 100/body surface area, and functional liver index (FLI) = [radioactivity (hepatocytes)/radioactivity (injected)] × 100/liver volume. We compared these indices with biochemical and histopathological results.
RESULTS: Univariate and multivariate analyses showed that FLI, LUV, LHL15, and prothrombin time were significant independent predictors of severe fibrosis. On the basis of receiver operating characteristics analysis, the areas under curve values of FLI, LUV, LHL15, and prothrombin time for predicting severe fibrosis were 0.83, 0.73, 0.69, and 0.68, respectively. Using an FLI value of 0.053, it was possible to predict severe fibrosis with 65 % sensitivity, 88 % specificity, and 76 % accuracy.
CONCLUSION: Assessment of functional hepatocytes by use of (99m)Tc-GSA SPECT/CT fused images is useful for identifying pathological liver fibrosis.
MATERIALS AND METHODS: On the basis of pathological findings we divided 161 patients into non-severe and severe fibrosis groups (n = 81 and n = 80, respectively). We measured 2 indices by (99m)Tc-GSA SPECT/CT fused imaging: liver uptake value (LUV) = [radioactivity (whole liver)/radioactivity (injected)] × 100/body surface area, and functional liver index (FLI) = [radioactivity (hepatocytes)/radioactivity (injected)] × 100/liver volume. We compared these indices with biochemical and histopathological results.
RESULTS: Univariate and multivariate analyses showed that FLI, LUV, LHL15, and prothrombin time were significant independent predictors of severe fibrosis. On the basis of receiver operating characteristics analysis, the areas under curve values of FLI, LUV, LHL15, and prothrombin time for predicting severe fibrosis were 0.83, 0.73, 0.69, and 0.68, respectively. Using an FLI value of 0.053, it was possible to predict severe fibrosis with 65 % sensitivity, 88 % specificity, and 76 % accuracy.
CONCLUSION: Assessment of functional hepatocytes by use of (99m)Tc-GSA SPECT/CT fused images is useful for identifying pathological liver fibrosis.
Предметные рубрики MeSH
AgedFemaleHepatitis, ChronicHumansImage Processing, Computer-AssistedLiverLiver CirrhosisLiver Function TestsMaleMultimodal ImagingPositron-Emission TomographyPredictive Value of TestsRadiopharmaceuticalsSensitivity and SpecificityTechnetium Tc 99m Aggregated AlbuminTechnetium Tc 99m PentetateTomography, Emission-Computed, Single-PhotonTomography, X-Ray Computed