Clinical biochemistry · 2012
Characterization of metalloproteinases, oxidative status and inflammation levels in the different stages of fibrosis in HCV patients.
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Capone F, Guerriero E, Sorice A, Maio P, Colonna G, Castello G, Costantini S
Аннотация
OBJECTIVES: This study was aimed at searching noninvasive markers of the transition from mild to severe fibrosis stage in HCV patients undergoing hepatic fibrosis.
DESIGN AND METHODS: Thirty-three patients affected by chronic HCV vs. twenty healthy donors were evaluated for the serum levels of several circulating matrix metalloproteinases (MMPs), TRAIL and β-NGF by multiplex biometric ELISA based immunoassay and anti- and pro-oxidant status (d-ROMs, BAP and NO) using a Diacron automated method.
RESULTS: HCV patients displayed increased expression levels of MMP-8, MMP-9, TRAIL and β-NGF, and an imbalance between pro- and antioxidant status, that contribute to liver fibrosis.
CONCLUSIONS: Since the determination of these parameters represents a reliable and easily applicable method, these parameters are suggested as serum surrogate markers for HCV patients in the routine clinical practice.
DESIGN AND METHODS: Thirty-three patients affected by chronic HCV vs. twenty healthy donors were evaluated for the serum levels of several circulating matrix metalloproteinases (MMPs), TRAIL and β-NGF by multiplex biometric ELISA based immunoassay and anti- and pro-oxidant status (d-ROMs, BAP and NO) using a Diacron automated method.
RESULTS: HCV patients displayed increased expression levels of MMP-8, MMP-9, TRAIL and β-NGF, and an imbalance between pro- and antioxidant status, that contribute to liver fibrosis.
CONCLUSIONS: Since the determination of these parameters represents a reliable and easily applicable method, these parameters are suggested as serum surrogate markers for HCV patients in the routine clinical practice.
Предметные рубрики MeSH
AntioxidantsBiomarkersCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleHepacivirusHepatitis C, ChronicHumansInflammationLiver CirrhosisMaleMatrix Metalloproteinase 8Matrix Metalloproteinase 9Middle AgedNerve Growth FactorNitric OxideOxidative StressSensitivity and SpecificityTNF-Related Apoptosis-Inducing Ligand