Georgian medical news · 2025
EVALUATION OF THE DEEP INSPIRATION BREATH-HOLD TECHNIQUE TO IMPROVE DOSIMETRIC OUTCOMES IN RADIOTHERAPY FOR STAGE III NON-SMALL CELL LUNG CANCER.
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Nabizade U, Isayev O, Haci G, Kazimov K, Nasirova G, Kaziyeva R, Guliyev E, Isayev I
Аннотация
BACKGROUND: Radiotherapy is a key treatment for stage III non-small cell lung cancer (NSCLC), but tumor proximity to critical structures-such as the heart, esophagus, and spinal cord and respiratory motion complicates dose delivery. The Deep Inspiration Breath Hold (DIBH) technique actively controls respiratory motion, potentially improving treatment precision.
METHODS: This retrospective study included 56 patients with stage III NSCLC. Each underwent two CT scans: one during free breathing (FB) and one using DIBH. Dosimetric parameters for organs at risk (OARs) were compared between FB (with a 6 mm internal target volume margin) and DIBH plans using paired Student's t-tests.
RESULTS: DIBH increased total lung volume by 28% and reduced heart volume by 12.5%. Lung dose metrics improved significantly with DIBH, including V5, V20, and mean lung dose (all P < 0.001). Heart dose parameters (V10, V40, mean dose) also decreased. DIBH significantly reduced both maximum and mean doses to the esophagus and maximum dose to the spinal cord.
CONCLUSIONS: In stage III NSCLC, DIBH significantly lowers radiation exposure to OARs and enhances dose delivery accuracy. By expanding lung volume, it may reduce the risk of radiation-induced pneumonitis.
METHODS: This retrospective study included 56 patients with stage III NSCLC. Each underwent two CT scans: one during free breathing (FB) and one using DIBH. Dosimetric parameters for organs at risk (OARs) were compared between FB (with a 6 mm internal target volume margin) and DIBH plans using paired Student's t-tests.
RESULTS: DIBH increased total lung volume by 28% and reduced heart volume by 12.5%. Lung dose metrics improved significantly with DIBH, including V5, V20, and mean lung dose (all P < 0.001). Heart dose parameters (V10, V40, mean dose) also decreased. DIBH significantly reduced both maximum and mean doses to the esophagus and maximum dose to the spinal cord.
CONCLUSIONS: In stage III NSCLC, DIBH significantly lowers radiation exposure to OARs and enhances dose delivery accuracy. By expanding lung volume, it may reduce the risk of radiation-induced pneumonitis.