Gan to kagaku ryoho. Cancer & chemotherapy · 2025
[Pathological Complete Response to Chemotherapy in Four Cases of Pancreatic Cancer].
СтатьяКлинический случайАннотация на английскомНазвание и аннотация: Перевод пока не подготовлен
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Akashi Masanori, Hashimoto Kazuaki, Midorikawa Ryuta, Fukutomi Shogo, Arai Shoichiro, Goto Yuichi, Sakai Hisamune, Fujita Fumihiko, Hisaka Toru
Аннотация
While recent advances in chemotherapy for pancreatic cancer have improved treatment outcomes, pathological complete responses(pCR)remain rare. Here, we present four cases of pancreatic cancer in which a pCR was achieved following chemotherapy. Three cases were classified as borderline resectable and one was resectable. Two patients received gemcitabine+nab-paclitaxel, 1 received mFOLFIRINOX, and one received gemcitabine+S-1 therapy. Histopathological examination after resection revealed only fibrosis and scarring. No tumor cells were found in any of these cases, leading to diagnoses of pCR. Two of the 4 patients survived without recurrence for a long time. The other 2 patients experienced recurrence, one of whom died 8 months after surgery.