Nutrients · 2024
Do Herbal Supplements and Probiotics Complement Antibiotics and Diet in the Management of SIBO? A Randomized Clinical Trial.
Рандомизированное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Redondo-Cuevas Lucia, Belloch Lucia, Martín-Carbonell Vanesa, Nicolás Angela, Alexandra Iulia, Sanchis Laura, Ynfante Marina, Colmenares Michel, Mora María, Liebana Ana Reyes, Antequera Beatriz, Grau Francisco, Molés José Ramón, Cuesta Rubén, Díaz Samuel, Sancho Noelia, Tomás Héctor, Gonzalvo José, Jaén Mercedes, Sánchez Eva, Garayoa Ana, Moreno Nadia, Gallén Ana, Cortés-Castell Ernesto, Cortés-Rizo Xavier
Аннотация
Small intestinal bacterial overgrowth (SIBO) arises from dysbiosis in the small intestine, manifesting with abdominal symptoms. This study aims to assess the efficacy of combined antibiotic therapy, herbal supplements, probiotics, and dietary modifications in SIBO management. A total of 179 SIBO-diagnosed patients underwent clinical evaluation and breath testing. Patients were categorized into hydrogen (H2-SIBO) and methane (CH4-SIBO) groups. The control group received standard antibiotic therapy and a low-FODMAP diet, while the intervention group received additional herbal antibiotics, probiotics, and prebiotics. After treatment, both groups exhibited reduced gas levels, particularly in CH4-SIBO. Clinical remission rates were higher in the intervention group, especially in CH4-SIBO cases. Logistic regression analysis showed gas concentrations at diagnosis as significant predictors of treatment success. In conclusion, adjunctive herbal supplements and probiotics did not significantly impact gas levels, but showed potential for clinical improvement, especially in CH4-SIBO.