Alternative therapies in health and medicine · 2025
Treatment of Polycystic Ovary Syndrome with Infertility by Dingkun Pills Combined with Ovulation-inducing Drugs: A Meta-Analysis.
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Ma Qianwen, Li Fei, Shen Mingxia, Wu Jianfei, Tan Yong, Ye Chenshu
Аннотация
OBJECTIVE: To compare the efficacy of the Dingkun pills combined with ovulation-inducing drugs and ovulation-inducing drugs alone in polycystic ovary syndrome (PCOS) with infertility by meta-analysis.
METHODS: PubMed, Cochrane Library, Web of Science (WoS), Chinese Biomedical Literature Database (CBM), CNKI, Wan Fang DATA, and VIP databases were searched. The relevant data were manually retrieved. The quality of the included studies was evaluated individually according to the Cochrane systematic evaluation method, and adequate data were extracted. Revman 5.3 software was used for the meta-analysis.
RESULTS: Fourteen randomized controlled trials (1338 patients) were included. The results showed that the experimental group (treated with Dingkun pills combined with ovulation-inducing drugs) was better than the control group (treated with ovulation-inducing drugs) in ovulation rate (95% CI 2.48, 4.70, P < .0001), pregnancy rate (95%CI 2.47, 4.11, P < .00001), endometrial thickness (95%CI 3.12, 3.23, P < .00001), luteinizing hormone (LH) level (95%CI -1.94, -0.71, P < .0001), oestradiol (E2) level (95%CI-22.84, -6.95, P = .0002), overall treatment efficacy (95% CI 2.62, 9.41, P < .00001), biochemical pregnancy rate (95% CI 2.62, 9.41, P < .00001), mature follicle rate (95%CI0.13, 0.84, P = .02), LUFS (luteinized unruptured follicle syndrome) rate (95%CI0.09, 0.63, P = .004), abnormal follicle count (95% CI -4.22, -3.97, P < .00001), ovarian volume (95% CI -3.01, -2.27, P < .00001), immature follicle count (95% CI 0.05, 0.52, P = .002), and mature follicle count (95% CI 0.34, 1.03. Z=3.87. P = .0001).
CONCLUSIONS: The efficacy of the experimental group in treating Polycystic Ovary Syndrome with infertility was better than that of the control group. However, the included literature only included Chinese articles. The quality of the study was low. Further high-quality clinical trials are required to confirm these findings.
METHODS: PubMed, Cochrane Library, Web of Science (WoS), Chinese Biomedical Literature Database (CBM), CNKI, Wan Fang DATA, and VIP databases were searched. The relevant data were manually retrieved. The quality of the included studies was evaluated individually according to the Cochrane systematic evaluation method, and adequate data were extracted. Revman 5.3 software was used for the meta-analysis.
RESULTS: Fourteen randomized controlled trials (1338 patients) were included. The results showed that the experimental group (treated with Dingkun pills combined with ovulation-inducing drugs) was better than the control group (treated with ovulation-inducing drugs) in ovulation rate (95% CI 2.48, 4.70, P < .0001), pregnancy rate (95%CI 2.47, 4.11, P < .00001), endometrial thickness (95%CI 3.12, 3.23, P < .00001), luteinizing hormone (LH) level (95%CI -1.94, -0.71, P < .0001), oestradiol (E2) level (95%CI-22.84, -6.95, P = .0002), overall treatment efficacy (95% CI 2.62, 9.41, P < .00001), biochemical pregnancy rate (95% CI 2.62, 9.41, P < .00001), mature follicle rate (95%CI0.13, 0.84, P = .02), LUFS (luteinized unruptured follicle syndrome) rate (95%CI0.09, 0.63, P = .004), abnormal follicle count (95% CI -4.22, -3.97, P < .00001), ovarian volume (95% CI -3.01, -2.27, P < .00001), immature follicle count (95% CI 0.05, 0.52, P = .002), and mature follicle count (95% CI 0.34, 1.03. Z=3.87. P = .0001).
CONCLUSIONS: The efficacy of the experimental group in treating Polycystic Ovary Syndrome with infertility was better than that of the control group. However, the included literature only included Chinese articles. The quality of the study was low. Further high-quality clinical trials are required to confirm these findings.