Journal of family medicine and primary care · 2025
Seroprevalence of hepatitis D virus infection among hepatitis B virus-infected patients attending UPUMS, Saifai: A cross-sectional study.
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Nishad Keshaw, Singh Dharmendra P, Verma Rajesh K, Chaudhary Radhika, Yaduvanshi Nidhi
Аннотация
CONTEXT: HDV is a defective RNA virus that requires HBV for the replication; therefore, HDV can only get transmitted to the people who also have HBV infection and lead severe liver disease. Globally, the geographical distribution of HDV infection among HBV-positive people is very heterogeneous. In India, limited data are available on prevalence of HDV among hepatitis B surface antigen (HBsAg)-positive patients. In our state, Uttar Pradesh, or region, there is lack of data on seroprevalence of HDV infection.
AIM: The aim of our study was to determine the seroprevalence of HDV infection among HBsAg-positive cases.
METHODS AND MATERIAL: This hospital-based cross-sectional study was carried out in the Department of Microbiology. 87 HBsAg-positive samples were included in the study. HBsAg-positive samples were subjected to anti HDV IgM and IgG ELISA Kit by Elabscience®. Demographic profiles and clinical parameters were taken from all the patients.
RESULTS: The mean age of HBsAg-positive patients was 36.6 years (SD: 14.6), with a male: female ratio of 2:1. Out of 87 HBsAg-positive patients, serological evidence of delta virus infection was observed in 6 patients (6.8%); 4 (4.6%) patients were positive for anti HDV IgG antibodies, and 2 (2.3%) were positive for anti HDV IgM antibodies.
CONCLUSIONS: This study provides evidence that seroprevalence of HDV coinfection in the case of Hepatitis B is low (6.8%) in the western part of Uttar Pradesh; understanding the seroprevalence of Hepatitis D helps public health authorities to allocate resources effectively and design target interventions.
AIM: The aim of our study was to determine the seroprevalence of HDV infection among HBsAg-positive cases.
METHODS AND MATERIAL: This hospital-based cross-sectional study was carried out in the Department of Microbiology. 87 HBsAg-positive samples were included in the study. HBsAg-positive samples were subjected to anti HDV IgM and IgG ELISA Kit by Elabscience®. Demographic profiles and clinical parameters were taken from all the patients.
RESULTS: The mean age of HBsAg-positive patients was 36.6 years (SD: 14.6), with a male: female ratio of 2:1. Out of 87 HBsAg-positive patients, serological evidence of delta virus infection was observed in 6 patients (6.8%); 4 (4.6%) patients were positive for anti HDV IgG antibodies, and 2 (2.3%) were positive for anti HDV IgM antibodies.
CONCLUSIONS: This study provides evidence that seroprevalence of HDV coinfection in the case of Hepatitis B is low (6.8%) in the western part of Uttar Pradesh; understanding the seroprevalence of Hepatitis D helps public health authorities to allocate resources effectively and design target interventions.