An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Yuqiong, Du Lamei, Wu Han, Li Hu, Liu Jiaqi, Hu Yongyan, Jiang Xinran, Yin Dedong, Hao Yongcun, Xiao Ao, Yang Yawen, Zhou Jingkun, Lin Long, Chen Feng, Ye Denglin, He Yuhui, Zhao Zhixiong, Liu Baoyu, Yao Kuanming, Wang Xiaohong, Chen Xi, Tong Yihang, Yao Fuqi, Yang Kuan, Sun Hong, Fu Yanzhe, Wang Siqi, Huang Zhaocun, Chen Xinyi, Guo Hao, Kong Shenshen, Yang Shaohua, Song Wenjing, Ershad Faheem, Wang Yang, Zhang Li, Zhang Qiuting, Wu Hao, Li Ning, Rao Wei, Li Jiebo, Yang Li, Chen Xing, Mu Wei, Yu Xinge, Fan Yubo, Yu Cunjiang, Xu Ye, Chang Lingqian
Аннотация
Efficient and precise delivery of therapeutics toward target loci of organs is crucial for effective disease therapy. However, conventional devices face remarkable challenges to achieve clinically desirable conformality, spatial controllability, and efficiency, especially to organs with complex anatomies, due to a lack of appropriate mechanical and/or material properties. Here, we report a bioelectronic patch for organ-conformal, kirigami-structured electro-transfection (POCKET) that features high conformality enabled by parametric customization, achieving a theoretically maximum effective coverage area over the target organ. The four-layered POCKET forms a unique nanopore-cell juxtaposition configuration at the tissue-device interface, which induces precise, uniform electro-perforation while expediting intracellular transport of payloads. The high delivery efficiency and precise spatial controllability have been systematically validated with various organs. POCKET-mediated therapeutic delivery achieved organ protection from accumulated DNA damage or ischemia-reperfusion injury, restoring organ functionalities. This work presents a customizable technique with translational value for precise therapy in challenging target organs.