Impact of Soybean and Swimming Training Modifications on Inflammation, Neurogenesis and Cognitive Function in Polycystic Ovary Syndrome: Experimental and Bioinformatics Study.

BACKGROUND

Polycystic ovary syndrome (PCOS) may extend to cognitive impairments. This preclinical and experimental study investigates the physiological effects of PCOS on neurogenesis and cognitive function, emphasizing the potential benefits of lifestyle modifications and complementary and alternative medicine (CAM) interventions. The proposed study covers the synergistic effects of swimming and soybean supplementation on genetic networks (mRNA-lncRNAs) in the context of inflammation, oxidative stress, and cognitive impairment corresponding to PCOS.

MATERIALS AND

METHODS

In this bioinformatic and experimental study, the mice were categorized into five groups: the control, the polycystic group [mice were orally administered 0.5 mg/kg of letrozole for 6 weeks then received 45% high-fat diet (HFD) for 12 weeks], the polycystic group with swimming training (swimming for 5 days a week for 8 weeks), the polycystic group with soy supplement consumption (150 mg/kg), the polycystic group that received both swimming exercise and soy supplement intake. Gene expression was quantified using the real-time polymerase chain reaction (PCR) approach. mRNAs and lncRNAs were identified as potential diagnostic or prognostic biomarkers using a bioinformatics approach. Computational modeling technique is used to predict small molecules' binding affinity and orientation to a target protein.

RESULTS

Swimming exercise combined with soy isoflavone supplementation improved cognitive outcomes and neurogenesis in PCOS mice through upregulation of neurogenesis-related genes and restoration of hormonal balance, suggesting potential therapeutic benefits for PCOS-associated cognitive dysfunction. The observed increases in the expression of neurogenesis-related genes and improvements in hormonal balance suggest that these interventions may mitigate some of the cognitive impairments associated with PCOS.

CONCLUSION

The findings suggest that complementary and alternative medicine approaches offer therapeutic benefits for symptom mitigation and systemic health improvement in PCOS management.