Impact of intravesical BCG Therapy on quality of life in non-muscle-invasive bladder cancer: a prospective evaluation using the FACT-Bl questionnaire.
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Caño-Velasco J, Luis-Cardo A, Moreno-Cortés J C, Carrasco-Loras L, Astudillo-Campoverde J, Subiela J D, Lozano-Palacio F, Campistol-Torres M, Pichler R, Partl A, Lackner F, Giudice F Del, Carino D, García-Martín L A, Salamanca-Blanco P, Bielsa-Carrillo A, Pastor-Cordero A M, Bataller-Monfort V, Tello-Delsors A, Polanco-Pujol L, Lafuente-Puentedura A, Aragón-Chamizo J, Herranz-Amo F, Barbas-Bernardos G, González-Padilla D A, Villacampa-Aubá F, Sánchez-Zalabardo D, Robles-García J E, Miñana-López B, Moschini M, Soria F, D'Andrea D, Mertens L S, Teoh J Y C, Albisinni S, Pradere B, Hernández-Fernández C, en nombre de la Asociación Europea de Urología - Jóvenes Urólogos Académicos (EAU-YAU), Grupo de Trabajo Sobre Carcinoma Urotelial
Аннотация
MATERIALS AND METHODS: Prospective multicentre observational study from February 2022 to June 2024 in patients with NMIBC. Patients completed the FACT-Bl questionnaire before and after the induction course. The results of both questionnaires were compared with Student's t-test for paired data using IBM®SPSS-Statistics-25.
RESULTS: A total of 235 patients completed both questionnaires and were analysed. 97% of the series completed BCG induction. A worsening in the physical well-being(PWB) subscale(P < 0.05) and an improvement in the emotional well-being(EWB) subscale(P < 0.05) were observed in the total series of cases, without differences in total scores. In BCG-naive patients (90%), significant deterioration was observed in PWB subscale(P < 0.05) and FACT-Bl Trial Outcome Index(TOI) (P < 0.05). Patients over 75 years showed a statistically significant improvement in EWB, while those aged ≤75 years experienced significant declines in PWB, bladder cancer subscale (BlCS), and three total scores. Limitations include exclusive use of FACT-Bl questionnaire to assess QoL and limited sample size.
CONCLUSIONS: BCG induction therapy shows no significant impact on overall FACT-Bl scores but declines PWB and improves EWB subscales. Age and prior BCG exposure influence outcomes; notably, patients aged ≤75 show marked declines in PWB, BlCS and total FACT-Bl scores.