Melatonin.

Melatonin is a neurohormone that is secreted by the pineal gland and known to impact the sleep-wake cycle. Melatonin is regarded to be a safe and natural sleep aid. Since many people with tinnitus suffer sleep disturbance, melatonin has been studied as a therapeutic agent for tinnitus. A review of the literature suggests that melatonin has a beneficial effect on tinnitus, especially for patients with sleep disturbance, but it does not seem to modify the strength or frequency of the tinnitus.