Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies.
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Chalitsios Christos V, Markozannes Georgios, Papagiannopoulos Christos, Aglago Elom K, Berndt Sonja I, Buchanan Daniel D, Campbell Peter T, Cao Yin, Chan Andrew T, Dimou Niki, Drew David A, French Amy J, Georgeson Peter, Giannakis Marios, Gruber Stephen B, Gunter Marc J, Harrison Tabitha A, Hoffmeister Michael, Hsu Li, Huang Wen-Yi, Hullar Meredith A J, Huyghe Jeroen R, Lynch Brigid M, Moreno Victor, Newton Christina C, Nowak Jonathan A, Obón-Santacana Mireia, Ogino Shuji, Qu Conghui, Schmit Stephanie L, Steinfelder Robert S, Sun Wei, Thomas Claire E, Toland Amanda E, Trinh Quang M, Ugai Tomotaka, Um Caroline Y, Van Guelpen Bethany, Zaidi Syed H, Murphy Neil, Peters Ulrike, Phipps Amanda I, Tsilidis Konstantinos K
Аннотация
METHODS: Data from 2,772 colorectal cancer cases and 3,521 controls were pooled from four cohort studies within the Genetics and Epidemiology of Colorectal Cancer Consortium. Four molecular markers (BRAF mutation, KRAS mutation, CpG island methylator phenotype, and microsatellite instability) were analyzed individually and in combination (Jass types). Multivariable logistic and multinomial logistic models were used to assess the associations of WC and ABSI with overall colorectal cancer risk and, in case-only analyses, to evaluate heterogeneity by molecular subtype, respectively.
RESULTS: Higher WC (ORper 5 cm = 1.06, 95% confidence interval, 1.04-1.09) and ABSI (ORper 1-SD = 1.07, 95% confidence interval, 1.00-1.14) were associated with elevated colorectal cancer risk. There was no evidence of heterogeneity between the molecular subtypes. No difference was observed regarding the influence of WC and ABSI on the four major molecular markers in proximal colon, distal colon, and rectal cancers, as well as in early- and late-onset colorectal cancers. Associations did not differ in the Jass-type analysis.
CONCLUSIONS: Higher WC and ABSI were associated with elevated colorectal cancer risk; however, they do not differentially influence all four major molecular mutations involved in colorectal carcinogenesis but underscore the importance of maintaining a healthy body weight in colorectal cancer prevention.
IMPACT: The proposed results have potential utility in colorectal cancer prevention.