Somatic-type Malignancies of Germ Cell Origin: Molecular, Pathologic, and Clinical Features.

Somatic-type malignancies (STMs) arising in germ cell tumors are relatively rare, affecting 3% to 8% of patients. These neoplasms show aggressive clinical behavior and are frequently resistant to systemic therapy. In the current review, we provide a comprehensive clinicopathologic overview of these tumors, emphasizing new molecular findings that have improved our understanding of their pathogenesis. In all areas, we highlight special considerations related to the different histologic subtypes. We conclude with a brief mention of areas of uncertainty and areas that require further study.