Fragile histidine triad (FHIT) gene and its association with p53 protein expression in the progression of gall bladder cancer.

OBJECTIVE

Present study deals with LOH and MSI in FHIT gene and p53 expression in GBC, CC, XGC, and normal GB to elucidate the role of FHIT gene in gall bladder cancer.

METHODS

Five microsatellite markers D3S1217, D3S1300, D3S1313, D3S1600, and D3S2757, were selected.

RESULTS

Among GBC cases the frequency of MSI-H and LOH was 17.5% and 27.5%, respectively. Significant difference was found between GBC and normal GB (p = .02), and GBC and CC groups (p= .002) when LOH was compared.

CONCLUSIONS

Our results suggested CC might act as a preinvasive stage in the pathogenesis of GBC.