Experimental and molecular pathology · 2022
Alcohol: basic and translational research; 15th annual Charles Lieber &1st Samuel French satellite symposium.
СтатьяОбзорПоддержка правительства СШАПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Neuman Manuela G, Seitz Helmut K, Tuma Pamela L, Osna Natalia A, Casey Carol A, Kharbanda Kusum K, Cohen Lawrence B, Malnick Steve D H, Adhikari Raghabendra, Mitra Ramyajit, Dagur Raghubendra Singh, Ganesan Murali, Srinivas Chava, Madan Kumar Arumugam, New-Aaron Moses, Poluektova Larisa, Thomes Paul G, Rasineni Karuna, Opris Mihai, Teschke Rolf
Аннотация
The present review is based on the research presented at the symposium dedicated to the legacy of the two scientists that made important discoveries in the field of alcohol-induced liver damage: Professors C.S. Lieber and S.W. French. The invited speakers described pharmacological, toxicological and patho-physiological effects of alcohol misuse. Moreover, genetic biomarkers determining adverse drug reactions due to interactions between therapeutics used for chronic or infectious diseases and alcohol exposure were discussed. The researchers presented their work in areas of alcohol-induced impairment in lipid protein trafficking and endocytosis, as well as the role of lipids in the development of fatty liver. The researchers showed that alcohol leads to covalent modifications that promote hepatic dysfunction and injury. We concluded that using new advanced techniques and research ideas leads to important discoveries in science.