Spontaneous regression of a choroidal nevus with risk factors for growth.

We report the case of a 41-year-old woman with a choroidal nevus exhibiting recognized risk factors for malignant transformation who demonstrated spontaneous and progressive regression over a 6-year follow-up period. Spontaneous involution is a well-established phenomenon in cutaneous lesions, including melanocytic nevi and cutaneous malignant melanoma, and has occasionally been described in choroidal melanoma. However, spontaneous regression of choroidal nevus is exceedingly rare, with only 2 cases previously reported in the literature. The underlying mechanism is presumed to involve an immune-mediated response driven by melanocyte-specific T lymphocytes, predominantly cytotoxic CD8+ T cells.