Quantitative analysis of diethyl-IDA reflux. Comparison of controls and dyspeptic, gastric ulcerated, and gastrectomized patients.

The administration of a radioactive tracer through the liver cell and the elimination of bile following an induced vesicular contraction permits duodenogastric reflux to be objectively diagnosed without intubation. This quantitative study of the reflux using 99mTC diethyl-IDA is based on 214 patients and demonstrates: 1) a frequent association with the gastric ulcer, 2) a considerable frequency in gastric resection surgery with duodenogastric anastomosis, 3) a constant occurrence in gastric resection surgery using jejunogastric anastomosis. These findings point to the involvement of biliopancreatic reflux in the genesis of gastric ulcer as well as gastritis and carcinoma of the gastric stump.