[The relationship of duodeno-gastric reflux index to histological changes and nuclear DNA contents in gastric stump mucosa dysplasia].

Dysplasia of gastric stump mucosa in 35 cases was studied. Evaluation of the entero-gastric reflux index(EGRI) was carried out by a computer radioisotope scanning. Dysplasia nuclear DNA content was measured using an automatic image analysis system. The results showed: (1) The severity of dysplasia in gastric stump mucosa increased with the increase of the mean values of the EGRI. The difference among all groups was highly significant (P < 0.001). (2) There appeared to be a significant positive correlation between EGRI and IOD, 2cDI, AREA or FORM PF, the correlation coefficients were 0.8927 (P < 0.001), 0.8631 (P < 0.001), 0.7845 (0.001 < P < 0.005), 0.7692 (0.001 < P < 0.005), respectively. (3) Significant differences were found among all groups for the mean interval between initial surgery and endoscopic examination (P < 0.001). From this study, a close relationship between dysplasia and entero-gastric reflux of the gastric stump could be postulated.