Clinica chimica acta; international journal of clinical chemistry · 2013
TNF-alpha promoter region polymorphisms affect HBV virus clearance in southern Chinese.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Xu Jianhua, Zhang Sanjiao, Zhang Zhaofeng, Fu Lingyuan, Zheng Qiupeng, Wang Jian, Lu Shengzhen, Du Jing
Аннотация
BACKGROUND: There are many cytokines, including TNF-α, TGFβ, PGF, and other factors contributing towards fibrogenesis, that play a role in the control of HBV infection. Among these, TNF-α is the most important cytokine in host immune response to viral infection. This study aimed to determine whether differences in the promoter region of the TNF-α gene may alter the outcomes of HBV infection.
METHODS: Two polymorphisms of tumor necrosis factor-α (TNF-α) gene, -308 G/A (rs1800629) and -863 C/A (rs1800630), were analyzed by DNA sequence in the case-control sample using 171 chronic HBV-infected patients and 227 recovered HBV-infected controls. All subjects were unrelated southern Han Chinese.
RESULTS: For TNF-α-308, healthy controls compared to HBV infection have a significantly higher allele A and GA genotype frequency. For TNF-α-863, no significant differences in allele or genotype frequencies between the case groups and the control group were observed.
CONCLUSIONS: This study provides evidence of a positive association between HBV clearance and TNF-α-308A.
METHODS: Two polymorphisms of tumor necrosis factor-α (TNF-α) gene, -308 G/A (rs1800629) and -863 C/A (rs1800630), were analyzed by DNA sequence in the case-control sample using 171 chronic HBV-infected patients and 227 recovered HBV-infected controls. All subjects were unrelated southern Han Chinese.
RESULTS: For TNF-α-308, healthy controls compared to HBV infection have a significantly higher allele A and GA genotype frequency. For TNF-α-863, no significant differences in allele or genotype frequencies between the case groups and the control group were observed.
CONCLUSIONS: This study provides evidence of a positive association between HBV clearance and TNF-α-308A.