The European journal of surgery = Acta chirurgica · 1998
Comparison between plain and gentamicin containing collagen sponges in infected peritoneal cavity in rats.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Vaneerdeweg W, Bresseleers T, Du Jardin P, Lauwers P, Pauli S, Thyssens K, Van Marck E, Elseviers M, Eyskens E
Аннотация
OBJECTIVE: To study the usefulness of gentamicin-containing sponges in the infected peritoneal cavity in rats.
DESIGN: Controlled study.
MATERIAL: 83 Male Wistar rats, 36 of which were treated by plain sponge, 36 by gentamicin-impregnated sponge, and 11 acted as controls.
INTERVENTIONS: A standard model of intraperitoneal infection was developed by making a 1 cm long incision in the caecum.
MAIN OUTCOME MEASURES: Postoperative mortality, macroscopic and microscopic features of infection, and bacterial concentrations in the abdomen on days 3, 6, and 9.
RESULTS: In the respective groups 2, 3 and 2 animals died during operation and 4/34 (11%), 3/33 (9%); and 0/9 died before day 3. There were appreciable reductions in the number of animals with features of infection after 3 days but these were not significant at 6 or 9 days.
CONCLUSION: Gentamicin-containing collagen sponges placed on a septic focus in the abdomen reduce local infection for at least 3 days.
DESIGN: Controlled study.
MATERIAL: 83 Male Wistar rats, 36 of which were treated by plain sponge, 36 by gentamicin-impregnated sponge, and 11 acted as controls.
INTERVENTIONS: A standard model of intraperitoneal infection was developed by making a 1 cm long incision in the caecum.
MAIN OUTCOME MEASURES: Postoperative mortality, macroscopic and microscopic features of infection, and bacterial concentrations in the abdomen on days 3, 6, and 9.
RESULTS: In the respective groups 2, 3 and 2 animals died during operation and 4/34 (11%), 3/33 (9%); and 0/9 died before day 3. There were appreciable reductions in the number of animals with features of infection after 3 days but these were not significant at 6 or 9 days.
CONCLUSION: Gentamicin-containing collagen sponges placed on a septic focus in the abdomen reduce local infection for at least 3 days.