[Evaluation of non-invasive scores in the follow-up of chronic hepatitis].

To differentiate biliary diseases the biopsy of liver tissue for histological examination is still the method of choice (golden standard). By histology the exact grading (inflammatory activity) and staging (of fibrosis) is possible. Hereby, the severity of liver disease and the progress of fibrosis can be determined. None of the various fibrosis marker like hyaluronate or collagen III peptid are able to replace the histology, neither alone nor as score. These biochemical marker and clinical parameter are suitable to follow up the progress of the detected fibrosis using the so-called noninvasive staging and to reduce the number of follow up biopsies. In fast progression of liver fibrosis the follow up by biopsy is almost more affirmative. For non-invasive follow ups the particular parameter hyaluronate is qualified best, according to the actual literature. Scores must keep on being evaluated on its value.