European heart journal. Case reports · 2025
Stuck between a rock and a hard place: heart failure with bilateral atrial appendage thrombi and disseminated intravascular coagulation-a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mazzeo Pietro, Bufano Gabriella, Fioretti Vincenzo, Corbo Maria Delia, Stabile Eugenio
Аннотация
BACKGROUND: The simultaneous occurrence of left atrial appendage (LAA) and right atrial appendage (RAA) thrombosis is a rare finding in atrial fibrillation (AF). In addition, concomitant conditions, such as heart failure (HF) and disseminated intravascular coagulation (DIC), could be associated with intracardiac thrombosis. Morganella morganii is an emerging pathogen, and the association with DIC and cardiac thrombosis is not yet described.
CASE SUMMARY: A 69-year-old Caucasian man was admitted to the hospital for progressive dyspnoea and new-onset diarrhoea. His physical examination revealed signs of HF and new-onset AF; laboratory tests showed marked thrombocytopaenia and coagulopathy. Blood and urine cultures were positive for M. morganii, and the International Society on Thrombosis and Hemostasis criteria were diagnostic for DIC. Transthoracic echocardiogram revealed a large, mobile left atrial mass and severely reduced left ventricular function. Transoesophageal echocardiogram showed two masses: one in the LAA and one in the RAA. Positron emission tomography/computed tomography scan excluded infective endocarditis and malignancies. After the beginning of antibiotic therapy and anticoagulation, the patient developed severe bleeding. Unfortunately, his haemodynamic status was complicated by multi-organ failure, and at the end, he developed irreversible cardiogenic shock. We present this challenging case of HF and AF complicated by DIC in the context of M. morganii infection.
DISCUSSION: Multiple mechanisms, such as inflammatory storm, activation of coagulation cascade, and amplified immune response, may explain the hyper-coagulable state related to DIC. In our case, HF, AF, and DIC may have facilitated RAA thrombosis, which is a rare finding. To the best of our knowledge, this is the first reported case of concomitant cardiac thrombosis as a complication of DIC in the context of M. morganii infection. This highlights the need among clinicians for an increased awareness about this pathogen and the complications of its infection.
CASE SUMMARY: A 69-year-old Caucasian man was admitted to the hospital for progressive dyspnoea and new-onset diarrhoea. His physical examination revealed signs of HF and new-onset AF; laboratory tests showed marked thrombocytopaenia and coagulopathy. Blood and urine cultures were positive for M. morganii, and the International Society on Thrombosis and Hemostasis criteria were diagnostic for DIC. Transthoracic echocardiogram revealed a large, mobile left atrial mass and severely reduced left ventricular function. Transoesophageal echocardiogram showed two masses: one in the LAA and one in the RAA. Positron emission tomography/computed tomography scan excluded infective endocarditis and malignancies. After the beginning of antibiotic therapy and anticoagulation, the patient developed severe bleeding. Unfortunately, his haemodynamic status was complicated by multi-organ failure, and at the end, he developed irreversible cardiogenic shock. We present this challenging case of HF and AF complicated by DIC in the context of M. morganii infection.
DISCUSSION: Multiple mechanisms, such as inflammatory storm, activation of coagulation cascade, and amplified immune response, may explain the hyper-coagulable state related to DIC. In our case, HF, AF, and DIC may have facilitated RAA thrombosis, which is a rare finding. To the best of our knowledge, this is the first reported case of concomitant cardiac thrombosis as a complication of DIC in the context of M. morganii infection. This highlights the need among clinicians for an increased awareness about this pathogen and the complications of its infection.