Nutrition (Burbank, Los Angeles County, Calif.) · 2025
Relationship between fecal microbiota and daily dietary macronutrient intake in male and female patients with hepatitis C virus-cirrhosis: A pilot study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Escalona-Nandez Ivonne, Palacios-Gonzalez Berenice, Estanes-Hernández Alma, Guevara-Cruz Martha, Torre-Delgadillo Aldo, Granados-Arreola Julio, Medina-Vera Isabel, Noriega Lilia G, Pérez-Monter Carlos
Аннотация
OBJECTIVES: Hepatitis C virus (HCV)-cirrhosis is associated with fecal microbiota (FM) imbalances, which may contribute to disease progression. Nutritional interventions can modify FM composition. However, the potential influence of sex in these interactions remains unexplored. We sought to characterize sex-specific FM differences during HCV-cirrhosis and their correlation with dietary intake.
METHODS: For this pilot study, we recruited men and women with or without HCV-cirrhosis to collect blood and stool samples. We assessed biochemical parameters, inflammatory cytokines, and FM. Multiple-pass 24-hour dietary recalls were analyzed using the Food-Processor software, and FM and macronutrient intake associations were evaluated with Pearson correlations.
RESULTS: Patients with HCV-cirrhosis exhibited elevated hepatic enzymes, increased inflammatory cytokines, and lower bacterial diversity than healthy controls. Male individuals with HCV-cirrhosis had increased Veillonella abundance, while women had higher Bifidobacterium and Butyricimonas. Dietary analysis revealed women with HCV-cirrhosis consumed more mono- and disaccharides and less protein and cholesterol. Pearson correlations showed that Bifidobacterium and UBA1819 were positively associated with calorie, protein, carbohydrate, and fat intake in women with HCV-cirrhosis. Veillonella positively correlated with mono- and disaccharides, while Ruminococcaceae were linked to fat intake in male individuals with HCV-cirrhosis.
CONCLUSION: In this pilot study, HCV-cirrhosis presents sex-specific FM differences, suggesting potential microbial signatures. Dietary modifications correlated with microbiota shifts, highlighting the importance of diet-microbiota interactions and the need for targeted dietary interventions to improve patient outcomes.
METHODS: For this pilot study, we recruited men and women with or without HCV-cirrhosis to collect blood and stool samples. We assessed biochemical parameters, inflammatory cytokines, and FM. Multiple-pass 24-hour dietary recalls were analyzed using the Food-Processor software, and FM and macronutrient intake associations were evaluated with Pearson correlations.
RESULTS: Patients with HCV-cirrhosis exhibited elevated hepatic enzymes, increased inflammatory cytokines, and lower bacterial diversity than healthy controls. Male individuals with HCV-cirrhosis had increased Veillonella abundance, while women had higher Bifidobacterium and Butyricimonas. Dietary analysis revealed women with HCV-cirrhosis consumed more mono- and disaccharides and less protein and cholesterol. Pearson correlations showed that Bifidobacterium and UBA1819 were positively associated with calorie, protein, carbohydrate, and fat intake in women with HCV-cirrhosis. Veillonella positively correlated with mono- and disaccharides, while Ruminococcaceae were linked to fat intake in male individuals with HCV-cirrhosis.
CONCLUSION: In this pilot study, HCV-cirrhosis presents sex-specific FM differences, suggesting potential microbial signatures. Dietary modifications correlated with microbiota shifts, highlighting the importance of diet-microbiota interactions and the need for targeted dietary interventions to improve patient outcomes.