Drug research · 2020
Development of the Composition of the Biopolymer Base for Nasal Gel.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Bakhrushina Elena, Demina Natalya, Krasnyuk Ivan, Moiseeva Anna
Аннотация
UNLABELLED: In many cases the nasal cavity is the gateway for the infection; it necessitates the development of a drug for nasal administration with antiviral, adsorptive and protective properties. Gels were chosen as an optimal dosage form. The study is aimed at studying the properties of biopolymer gelling agents and determining the composition of the future dosage form.
MATERIALS AND METHODS: Gel samples with 3, 4 and 5% concentrations were prepared using the following gelling agents: sodium alginate Protanal CR8223, Protanal CR8133, Manucol LKХ (FMC BioPolymer) and xanthan gum GrinstedXanthan (DuPontDanisco), Xanthural 180 (CP Kelco). Adsorption and osmotic activity, bioadhesion and thermostability of the samples were determined.
RESULTS: Basing on the totality of the obtained results, 3 compositions prospective for the dosage form development were selected: xanthan gums (particle size 180pm) from various manufacturers: Grinsted Xanthan 3 and 4% concentrations, Xanthural 180 5% concentration. These compositions possess high adsorption activity (25.06; 21.35; 20.6 g respectively), optimal osmotic activity (155, 171, 100%) and have significant bioadhesion (28.4421; 22.7237; 30.2835 N) that allows the drug to stay in the nasal cavity for a long period of time. All selected compositions demonstrated good high-temperature stability.
CONCLUSION: The obtained data shows prospects of applying the samples for the development of nasal gel with an immunobiological substance.
MATERIALS AND METHODS: Gel samples with 3, 4 and 5% concentrations were prepared using the following gelling agents: sodium alginate Protanal CR8223, Protanal CR8133, Manucol LKХ (FMC BioPolymer) and xanthan gum GrinstedXanthan (DuPontDanisco), Xanthural 180 (CP Kelco). Adsorption and osmotic activity, bioadhesion and thermostability of the samples were determined.
RESULTS: Basing on the totality of the obtained results, 3 compositions prospective for the dosage form development were selected: xanthan gums (particle size 180pm) from various manufacturers: Grinsted Xanthan 3 and 4% concentrations, Xanthural 180 5% concentration. These compositions possess high adsorption activity (25.06; 21.35; 20.6 g respectively), optimal osmotic activity (155, 171, 100%) and have significant bioadhesion (28.4421; 22.7237; 30.2835 N) that allows the drug to stay in the nasal cavity for a long period of time. All selected compositions demonstrated good high-temperature stability.
CONCLUSION: The obtained data shows prospects of applying the samples for the development of nasal gel with an immunobiological substance.