European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2026
Tumor burden score determines survival benefit of anatomic resection in hepatocellular carcinoma: A multicenter propensity-matched study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Pang Shujie, Shi Yang, Jiang Minjun, Ye Qingwang, Yan Xin, Sun Zhe, Kou Xingrui, Chen Xiaoxiang, SiMa Hui, Chen Yiming, Yang Yingcheng, Yang Ning
Аннотация
BACKGROUND: The survival benefit of wide-margin or anatomic resection for hepatocellular carcinoma (HCC) is debated, necessitating practical preoperative predictors.
METHODS: This multicenter retrospective study analyzed 635 HCC patients (2016-2023) comparing recurrence-free survival (RFS) after wide vs. narrow margin and anatomic vs. non-anatomic resections. Tumor burden score (TBS) was defined as √[(max diameter)2+ (tumor number)2]. Patients were stratified by TBS (high >5, low ≤5). Propensity score matching (PSM) balanced confounders in the high-TBS cohort for RFS comparison.
RESULTS: Margin width did not affect RFS. Anatomic resection significantly improved RFS only in high-TBS patients (p = 0.002), not in low-TBS patients. After PSM adjusted for baseline imbalances in the high-TBS cohort, the RFS benefit of anatomic resection remained significant (p = 0.012).
CONCLUSION: TBS is an effective preoperative predictor, identifying high tumor burden patients who derive significant RFS benefit from anatomic resection.
METHODS: This multicenter retrospective study analyzed 635 HCC patients (2016-2023) comparing recurrence-free survival (RFS) after wide vs. narrow margin and anatomic vs. non-anatomic resections. Tumor burden score (TBS) was defined as √[(max diameter)2+ (tumor number)2]. Patients were stratified by TBS (high >5, low ≤5). Propensity score matching (PSM) balanced confounders in the high-TBS cohort for RFS comparison.
RESULTS: Margin width did not affect RFS. Anatomic resection significantly improved RFS only in high-TBS patients (p = 0.002), not in low-TBS patients. After PSM adjusted for baseline imbalances in the high-TBS cohort, the RFS benefit of anatomic resection remained significant (p = 0.012).
CONCLUSION: TBS is an effective preoperative predictor, identifying high tumor burden patients who derive significant RFS benefit from anatomic resection.