Acta cirurgica brasileira · 2018
Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Mascena Guilherme Veras, Figueiredo Filho Carlos Alberto, Lima Júnior Marcos Antônio Xavier de, Oliveira Thárcia Kiara Beserra, Gadelha Diego Nery Benevides, Melo Maria Cecília Santos Cavalcanti, Brandt Carlos Teixeira
Аннотация
PURPOSE: To evaluate the response of aging rats with sepsis to two different antibiotic regimens.
METHODS: The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups: Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups.
RESULTS: At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967).
CONCLUSION: Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis.
METHODS: The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups: Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups.
RESULTS: At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967).
CONCLUSION: Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis.