Archives of oral biology · 2011
Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Barros Simone Souza Lobão Veras, Henriques Águida Cristina Gomes, Pereira Karuza Maria Alves, de Medeiros Ana Myriam Costa, Galvão Hébel Cavalcanti, Freitas Roseana de Almeida
Аннотация
OBJECTIVE: To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy.
STUDY DESIGN: Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy (n = 17) and high grade malignancy (n = 13).
RESULTS: Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 (P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 (P < 0.05) and MMP-26 (P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26.
CONCLUSION: The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue.
STUDY DESIGN: Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy (n = 17) and high grade malignancy (n = 13).
RESULTS: Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 (P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 (P < 0.05) and MMP-26 (P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26.
CONCLUSION: The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue.
Предметные рубрики MeSH
Carcinoma, Squamous CellCell NucleusDisease ProgressionHumansImmunohistochemistryInflammationKeratinsLip NeoplasmsMatrix Metalloproteinase 1Matrix Metalloproteinase 2Matrix Metalloproteinase 7Matrix Metalloproteinase 9Matrix MetalloproteinasesMatrix Metalloproteinases, SecretedNeoplasm InvasivenessStromal CellsTongue Neoplasms