Archives of otolaryngology--head & neck surgery · 2010
Squamous cell carcinoma of the oral tongue in the pediatric age group: a matched-pair analysis of survival.
Сравнительное исследованиеСтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Morris Luc G T, Patel Snehal G, Shah Jatin P, Ganly Ian
Аннотация
OBJECTIVE: To compare outcomes of a pediatric cohort of patients compared with a matched cohort of adult patients, all diagnosed as having squamous cell carcinoma (SCC) of the oral tongue. Outcomes of oral cancer in pediatric patients have not been studied, to our knowledge.
DESIGN: Retrospective matched-pair cohort study.
SETTING: Memorial Sloan-Kettering Cancer Center, New York, New York.
PATIENTS: A total of 10 pediatric and 40 adult patients diagnosed as having SCC of the oral tongue.
MAIN OUTCOME MEASURES: Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS).
RESULTS: The 5-year OS was equivalent in the 2 groups: 70% in the pediatric group and 64% in the adult group (P = .97). The 5-year DSS was also equivalent: 80% in the pediatric group and 76% in the adult group (P = .90). The 5-year RFS was 70% in the pediatric group and 78% in the adult group (P = .54).
CONCLUSIONS: When pediatric and adult patients were matched for sex, tobacco use history, TNM status, surgical procedure, and adjuvant radiotherapy, outcomes for OS, DSS, and RFS were equivalent. Pediatric patients with SCC of the oral tongue should be treated similarly to adult patients.
DESIGN: Retrospective matched-pair cohort study.
SETTING: Memorial Sloan-Kettering Cancer Center, New York, New York.
PATIENTS: A total of 10 pediatric and 40 adult patients diagnosed as having SCC of the oral tongue.
MAIN OUTCOME MEASURES: Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS).
RESULTS: The 5-year OS was equivalent in the 2 groups: 70% in the pediatric group and 64% in the adult group (P = .97). The 5-year DSS was also equivalent: 80% in the pediatric group and 76% in the adult group (P = .90). The 5-year RFS was 70% in the pediatric group and 78% in the adult group (P = .54).
CONCLUSIONS: When pediatric and adult patients were matched for sex, tobacco use history, TNM status, surgical procedure, and adjuvant radiotherapy, outcomes for OS, DSS, and RFS were equivalent. Pediatric patients with SCC of the oral tongue should be treated similarly to adult patients.
Предметные рубрики MeSH
AdolescentAdultAge FactorsBiopsy, NeedleCarcinoma, Squamous CellCohort StudiesCombined Modality TherapyDisease-Free SurvivalFemaleHumansImmunohistochemistryKaplan-Meier EstimateMaleMatched-Pair AnalysisNeoplasm Recurrence, LocalNeoplasm StagingOral Surgical ProceduresProbabilityRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentSurvival AnalysisTongue NeoplasmsYoung Adult