Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021
[Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in gastric cancer].
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Gronau Felix, Jara Maximilian, Feldbrügge Linda, Wolf Vincent, Oeff Alan, Rau Beate
Аннотация
BACKGROUND: Gastric cancer with peritoneal metastases is associated with an extremely poor prognosis. Developed multimodal treatment concepts, which include a combination of perioperative systemic treatment and cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC), show promising results with respect to improvement of the long-term survival.
METHODS: This article contains a review of the literature of published studies on the topic of gastric cancer and peritoneal metastasis.
RESULTS: The prognosis of patients with gastric cancer peritoneal carcinomatosis shows an extremely limited median survival of 7 months under palliative second-line systemic treatment. The median survival time increased to 12 months with cytoreductive surgery and in combination with HIPEC showed a positive effect on survival in individual studies.
EXPERT OPINION: Treatment recommendations for patients with peritoneal metastases of gastric cancer should be carried out by experts in surgical reference centers.
METHODS: This article contains a review of the literature of published studies on the topic of gastric cancer and peritoneal metastasis.
RESULTS: The prognosis of patients with gastric cancer peritoneal carcinomatosis shows an extremely limited median survival of 7 months under palliative second-line systemic treatment. The median survival time increased to 12 months with cytoreductive surgery and in combination with HIPEC showed a positive effect on survival in individual studies.
EXPERT OPINION: Treatment recommendations for patients with peritoneal metastases of gastric cancer should be carried out by experts in surgical reference centers.