Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2010
(99m)Tc-labeled-1-thio-beta-d-glucose as a new tool to temporomandibular joint inflammatory disorders diagnosis.
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Brasileiro Cláudia Borges, Pacheco Cinthia Mara da Fonseca, Queiroz-Junior Celso Martins, de Lima Carla Flávia, da Silva Juliana Batista, de Campos Tarcísio Passos Ribeiro
Аннотация
AIM: The aim of this study was to evaluate early detection of temporomandibular joint (TMJ) inflammatory changes based on 1-thio-beta-d-glucose radiolabeled with technetium-99m.
METHOD: The method applied a TMJ inflammation model in rats followed by radiopharmaceutical synthesis, intravenous administration of (99m)Tc-1-TG and kinetic scintigraphy imaging.
RESULTS: Results show a significant difference of (99m)Tc-1-TG uptake between inflamed TMJ and the control joint. The biodistribution of (99m)Tc-1-TG by images showed the kidneys' excretion.
CONCLUSION: As conclusion, (99m)Tc-1-TG is a helpful tool in TMJ inflammatory process detection.
METHOD: The method applied a TMJ inflammation model in rats followed by radiopharmaceutical synthesis, intravenous administration of (99m)Tc-1-TG and kinetic scintigraphy imaging.
RESULTS: Results show a significant difference of (99m)Tc-1-TG uptake between inflamed TMJ and the control joint. The biodistribution of (99m)Tc-1-TG by images showed the kidneys' excretion.
CONCLUSION: As conclusion, (99m)Tc-1-TG is a helpful tool in TMJ inflammatory process detection.