EMBO reports · 2017
LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis.
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Wu Xiang-Song, Wang Fang, Li Huai-Feng, Hu Yun-Ping, Jiang Lin, Zhang Fei, Li Mao-Lan, Wang Xu-An, Jin Yun-Peng, Zhang Yi-Jian, Lu Wei, Wu Wen-Guang, Shu Yi-Jun, Weng Hao, Cao Yang, Bao Run-Fa, Liang Hai-Bin, Wang Zheng, Zhang Yi-Chi, Gong Wei, Zheng Lei, Sun Shu-Han, Liu Ying-Bin
Аннотация
Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.