Evaluation of site-specific chemotherapeutic agents in periodontal treatment.

The rapid evolution of chemotherapeutic agents and site-specific treatment of adult periodontitis using controlled delivery systems require critical evaluation by the clinician. At present there are no defined guidelines to assist clinicians in their decision-making process. This paper offers background information and guidelines that can be applied to new and established chemotherapeutic agents and site-specific controlled delivery treatment modalities. The guidelines are not intended to be all inclusive or represent a definitive treatise on the subject. However, it is hoped that the factors addressed will serve as impetus for a discriminating consideration of the problems inherent to the evaluation of new therapeutic products, particularly those intended for use as site-specific controlled delivery modalities in the treatment of adult periodontitis.