Archives of medical research · 2024
In Vitro Human Endometrial Cells and In Vivo Rat Model Studies Suggest That Ulipristal Acetate Impacts Endometrial Compatibility for Embryo Implantation.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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García-Uribe Pablo Ángel, Hernández-Silva Gabriela, Vega Claudia Cecilia, Ordaz-Rosado David, Morales Angélica, Hernández-Pando Rogelio, García-Becerra Rocío, Díaz Lorenza, García-Quiroz Janice, Barrera David, Chirinos Mayel, Larrea Fernando
Аннотация
BACKGROUND: Ulipristal acetate (UPA) and levonorgestrel are used as emergency hormonal contraceptives. Although both are highly effective in preventing pregnancy, UPA shows efficacy even when taken up to 120 h after unprotected sexual intercourse.
AIMS: To investigate whether the mechanism of UPA's contraceptive action involves post-fertilization effects.
METHODS: In vitro and in vivo studies using cultured human endometrial cells and a pre-clinical rat model.
RESULTS: Endometrial cells treated with UPA showed changes in the expression of receptivity gene markers and a significant decrease in trophoblast spheroids attached to the cultured cells. In addition, administration of UPA to female unmated rats decreased the expression of implantation-related genes in the endometrium and inhibited the number of implantation sites in the mated group compared to the non-treated group.
CONCLUSIONS: These results support that UPA as an emergency contraceptive might have post-fertilization effects that may affect embryo implantation.
AIMS: To investigate whether the mechanism of UPA's contraceptive action involves post-fertilization effects.
METHODS: In vitro and in vivo studies using cultured human endometrial cells and a pre-clinical rat model.
RESULTS: Endometrial cells treated with UPA showed changes in the expression of receptivity gene markers and a significant decrease in trophoblast spheroids attached to the cultured cells. In addition, administration of UPA to female unmated rats decreased the expression of implantation-related genes in the endometrium and inhibited the number of implantation sites in the mated group compared to the non-treated group.
CONCLUSIONS: These results support that UPA as an emergency contraceptive might have post-fertilization effects that may affect embryo implantation.