The influence of 2-(4-methylaminobutoxy)diphenylmethane hydrochloride (MCI-2016) on gastric ulcer and gastric acid secretion.

The effect of 2-(4-methylaminobtoxy)diphenylmethane hydrochloride (MCI-2016) on the development of ulcers and on gastric secretion were examined in comparison with imipramine and amitriptyline. In various experimental ulcer models (Shay, water-immersion restraint, cold stress, swimming stress and reserpine ulcers), MCI-2016, at the doses ranging from 6.25 to 100 mg/kg p.o., exhibited a dose-dependent inhibition of ulceration with high therapeutic index. MCI-2016 showed little influence on the spontaneous and stimulated gastric secretion at the doses effectively suppressing the ulcer formation. In contrast, both imipramine and amitriptyline caused a significant inhibition of spontaneous and carbachol-stimulated gastric secretion. These results suggest that anti-cholinergic action is not involved in the anti-ulcer effect of MCI-2016. It may be further postulated that central norepinephrine (noradrenaline) uptake inhibition is related with the anti-ulcer action of MCI-2016.