The Journal of clinical endocrinology and metabolism · 2002
Ghrelin expression in islet cell tumors: augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I.
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Iwakura Hiroshi, Hosoda Kiminori, Doi Ryuichiro, Komoto Izumi, Nishimura Haruo, Son Choel, Fujikura Junji, Tomita Tsutomu, Takaya Kazuhiko, Ogawa Yoshihiro, Hayashi Tatsuya, Inoue Gen, Akamizu Takashi, Hosoda Hiroshi, Kojima Masayasu, Kangawa Kenji, Imamura Masayuki, Nakao Kazuwa
Аннотация
Ghrelin is a 28-amino acid peptide that regulates GH release together with GHRH and somatostatin. The expression of ghrelin has been detected in the stomach, small intestine, hypothalamus, pituitary gland, kidney, placenta, and testis. Recently it was reported that ghrelin is present in pancreatic alpha-cells and that it stimulates insulin secretion. In this study, we examined the ghrelin expression in two cases of glucagonoma and two cases of insulinoma by Northern blot analysis and immunohistochemistry. Ghrelin expression was identified in a case of glucagonoma associated with multiple endocrine neoplasm type I both by Northern blot analysis using total RNA and by immunohistochemistry, although the plasma ghrelin level was not elevated. This is the first case of tumor in which ghrelin gene expression was detected by Northern blot analysis using total RNA.