Fertility and sterility · 2001
Glucocorticoid hormone can suppress apoptosis of rat testicular germ cells induced by testicular ischemia.
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Yazawa H, Sasagawa I, Suzuki Y, Nakada T
Аннотация
OBJECTIVE: To evaluate the effect of dexamethasone, a potent synthetic glucocorticoid hormone, on apoptosis of testicular germ cells and vascular neutrophil adhesion after repair of testicular torsion in rats.
DESIGN: Controlled laboratory study.
SETTING: Department of Urology, Yamagata University School of Medicine, Yamagata, Japan.
ANIMAL(S): Fifty-one male Sprague-Dawley rats.
INTERVENTION(S): Dexamethasone, 10 mg/kg of body weight.
MAIN OUTCOME MEASURE(S): Testicular germ-cell apoptosis (percentages of apoptotic tubules and apoptotic cells) and vascular neutrophil adhesion were assessed by using DNA nick-end labeling and the endothelial-neutrophil adhesion score, respectively.
RESULT(S): Intravenous administration of dexamethasone at repair of 90-minute testicular torsion significantly inhibited testicular germ-cell apoptosis and vascular neutrophil adhesion. This inhibition was suppressed by intravenous injection of mifepristone, a glucocorticoid-receptor antagonist.
CONCLUSION(S): Glucocorticoids can be administered for torsion in addition to conventional torsion repair.
DESIGN: Controlled laboratory study.
SETTING: Department of Urology, Yamagata University School of Medicine, Yamagata, Japan.
ANIMAL(S): Fifty-one male Sprague-Dawley rats.
INTERVENTION(S): Dexamethasone, 10 mg/kg of body weight.
MAIN OUTCOME MEASURE(S): Testicular germ-cell apoptosis (percentages of apoptotic tubules and apoptotic cells) and vascular neutrophil adhesion were assessed by using DNA nick-end labeling and the endothelial-neutrophil adhesion score, respectively.
RESULT(S): Intravenous administration of dexamethasone at repair of 90-minute testicular torsion significantly inhibited testicular germ-cell apoptosis and vascular neutrophil adhesion. This inhibition was suppressed by intravenous injection of mifepristone, a glucocorticoid-receptor antagonist.
CONCLUSION(S): Glucocorticoids can be administered for torsion in addition to conventional torsion repair.