Obesity is associated with biliary tract cancer mortality and incidence: A pooled analysis of 21 cohort studies in the Asia Cohort Consortium.
СтатьяПоддержка правительства СШАПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Oze Isao, Ito Hidemi, Koyanagi Yuriko N, Abe Sarah Krull, Rahman Md Shafiur, Islam Md Rashedul, Saito Eiko, Gupta Prakash C, Sawada Norie, Tamakoshi Akiko, Shu Xiao-Ou, Sakata Ritsu, Malekzadeh Reza, Tsuji Ichiro, Kim Jeongseon, Nagata Chisato, You San-Lin, Park Sue K, Yuan Jian-Min, Shin Myung-Hee, Kweon Sun-Seog, Pednekar Mangesh S, Tsugane Shoichiro, Kimura Takashi, Gao Yu-Tang, Cai Hui, Pourshams Akram, Lu Yukai, Kanemura Seiki, Wada Keiko, Sugawara Yumi, Chen Chien-Jen, Chen Yu, Shin Aesun, Wang Renwei, Ahn Yoon-Ok, Shin Min-Ho, Ahsan Habibul, Boffetta Paolo, Chia Kee Seng, Qiao You-Lin, Rothman Nathaniel, Zheng Wei, Inoue Manami, Kang Daehee, Matsuo Keitaro
Аннотация
Body fatness is considered a probable risk factor for biliary tract cancer (BTC), whereas cholelithiasis is an established factor. Nevertheless, although obesity is an established risk factor for cholelithiasis, previous studies of the association of body mass index (BMI) and BTC did not take the effect of cholelithiasis fully into account. To better understand the effect of BMI on BTC, we conducted a pooled analysis using population-based cohort studies in Asians. In total, 905 530 subjects from 21 cohort studies participating in the Asia Cohort Consortium were included. BMI was categorized into four groups: underweight (<18.5 kg/m2 ); normal (18.5-22.9 kg/m2 ); overweight (23-24.9 kg/m2 ); and obese (25+ kg/m2 ). The association between BMI and BTC incidence and mortality was assessed using hazard ratios (HR) and 95% confidence intervals (CIs) by Cox regression models with shared frailty. Mediation analysis was used to decompose the association into a direct and an indirect (mediated) effect. Compared to normal BMI, high BMI was associated with BTC mortality (HR 1.19 [CI 1.02-1.38] for males, HR 1.30 [1.14-1.49] for females). Cholelithiasis had significant interaction with BMI on BTC risk. BMI was associated with BTC risk directly and through cholelithiasis in females, whereas the association was unclear in males. When cholelithiasis was present, BMI was not associated with BTC death in either males or females. BMI was associated with BTC death among females without cholelithiasis. This study suggests BMI is associated with BTC mortality in Asians. Cholelithiasis appears to contribute to the association; and moreover, obesity appears to increase BTC risk without cholelithiasis.