Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2013
Modelling the electric field and the current density generated by cerebellar transcranial DC stimulation in humans.
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Parazzini Marta, Rossi Elena, Ferrucci Roberta, Liorni Ilaria, Priori Alberto, Ravazzani Paolo
Аннотация
OBJECTIVE: Transcranial Direct Current Stimulation (tDCS) over the cerebellum (or cerebellar tDCS) modulates working memory, changes cerebello-brain interaction, and affects locomotion in humans. Also, the use of tDCS has been proposed for the treatment of disorders characterized by cerebellar dysfunction. Nonetheless, the electric field (E) and current density (J) spatial distributions generated by cerebellar tDCS are unknown. This work aimed to estimate E and J distributions during cerebellar tDCS.
METHODS: Computational electromagnetics techniques were applied in three human realistic models of different ages and gender.
RESULTS: The stronger E and J occurred mainly in the cerebellar cortex, with some spread (up to 4%) toward the occipital cortex. Also, changes by ±1cm in the position of the active electrode resulted in a small effect (up to 4%) in the E and J spatial distribution in the cerebellum. Finally, the E and J spreads to the brainstem and the heart were negligible, thus further supporting the safety of this technique.
CONCLUSIONS: Despite inter-individual differences, our modeling study confirms that the cerebellum is the structure mainly involved by cerebellar tDCS.
SIGNIFICANCE: Modeling approach reveals that during cerebellar tDCS the current spread to other structures outside the cerebellum is unlike to produce functional effects.
METHODS: Computational electromagnetics techniques were applied in three human realistic models of different ages and gender.
RESULTS: The stronger E and J occurred mainly in the cerebellar cortex, with some spread (up to 4%) toward the occipital cortex. Also, changes by ±1cm in the position of the active electrode resulted in a small effect (up to 4%) in the E and J spatial distribution in the cerebellum. Finally, the E and J spreads to the brainstem and the heart were negligible, thus further supporting the safety of this technique.
CONCLUSIONS: Despite inter-individual differences, our modeling study confirms that the cerebellum is the structure mainly involved by cerebellar tDCS.
SIGNIFICANCE: Modeling approach reveals that during cerebellar tDCS the current spread to other structures outside the cerebellum is unlike to produce functional effects.